| Main Title |
Comparison of Lung Antioxidant Levels in Humans and Laboratory Animals. |
| Author |
Slade, R. ;
Stead, A. G. ;
Graham, J. A. ;
Hatch, G. E. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1985 |
| Report Number |
EPA/600/J-85/309; |
| Stock Number |
PB86-162377 |
| Additional Subjects |
Antioxidants ;
Toxicity ;
Humans ;
Laboratory animals ;
Respiratory system ;
Reprints ;
Ascorbic acid ;
Sulfhydryls ;
Tocopherol
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-162377 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
Basal lung concentrations of ascorbic acid (AA), nonprotein sulfhydryls (NPSH), and a-tocopherol (a-T) were determined in rabbits, guinea pigs, rats, hamsters, mice, domestic pigs and sheep, and in human lung samples obtained from cancer surgery patients. Significant differences were found among the laboratory animals: AA levels ranged from 25.6 mg% (mg/100 g wet wt) in hamsters to 41.7 mg% in mice, NPSH from 50.9 mg% in rats to 84.7 mg% in rabbits, and a-T from 1.01 mg% in hamsters to 2.74 mg% in rats. Porcine lung AA and NPSH approximated those of the laboratory animals and their a-T levels were the highest of all species studied. Sheep lung AA levels were comparable to the other species, although their NPSH and a-T levels appeared to be lower. Human lung concentrations of NPSH (5.2 mg%) and a-T (0.85 mg%) appeared low, and the mean AA concentration (22.1 mg%) was similar to those of laboratory animals. |
| Supplementary Notes |
Pub. in American Review of Respiratory Diseases 131, n5 p742-746 May 85. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Comparison of Lung Antioxidant Levels in Humans and Laboratory Animals. |
| PUB Date Free Form |
1985 |
| Category Codes |
6P; 57S |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
611417760 |
| Origin |
NTIS |
| Type |
CAT |
