Main Title |
Characteristics of Benzo(a)Pyrene and A-Ring Reduced 7,12-Dimethyl Benz(a)Anthracene Induced Neoplastic Transformation of Human Cells in Vivo. |
Author |
Tejwani, R. ;
Witiak, D. T. ;
Inbasekaran, M. N. ;
Cazer, F. D. ;
Milo, G. E. ;
|
CORP Author |
Ohio State Univ., Columbus. Dept. of Physiological Chemistry.;Health Effects Research Lab., Research Triangle Park, NC.;Air Force Office of Scientific Research, Bolling AFB, DC.;National Cancer Inst., Bethesda, MD. |
Year Published |
1981 |
Report Number |
F49620-80-C-0085, EPA-R-806638; EPA-600/J-81-686; |
Stock Number |
PB84-174663 |
Additional Subjects |
Neoplasms ;
Toxicology ;
In vivo analysis ;
Humans ;
Cells(Biology) ;
Reprints ;
Carcinogenesis
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB84-174663 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
11p |
Abstract |
The polynuclear aromatic hydrocarbons (PAH) benzo(a)pyrene (BP) and the A-ring reduced analogue of 7,12-dimethylbenz(a)anthracene (DMBA), 1,2,3,4-tetrahydro-7,12-dimethylbenz(a)anthracene (TH-DMBA) are carcinogenic to human cells. The unsaturated PAH, DMBA exhibits no carcinogenic activity on human cells as measured by growth in soft agar of 84 and 86, respectively. These anchorage independent cells when seeded on the chick embryonic skin (CES) organ cultures, are invasive and form a fibrosarcoma. It is highly unlikely that TH-DMBA, which does not contain an aromatic A-ring, can undergo metabolism in human cells in culture to form a bay region 3,4-dihydrodiol-1,2-epoxide. These results suggest that an alternate mechanism for the induction of carcinogenesis is appropriate to explain the absence of bay region diol-epoxide metabolite as the ultimate form of the carcinogen in TH-DMBA induced carcinogenesis in human diploid cells. |
Supplementary Notes |
Sponsored in part by Grant PHS-CA-16058. |
Availability Notes |
Pub. in Cancer Letters, v13 p119-127 1981. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Characteristics of Benzo(a)Pyrene and A-Ring Reduced 7,12-Dimethyl Benz(a)Anthracene Induced Neoplastic Transformation of Human Cells in Vivo. |
PUB Date Free Form |
1981 |
Category Codes |
6T; 6C; 57Y; 57F |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
417425664 |
Origin |
NTIS |
Type |
CAT |