| Main Title |
Aluminum Alters Calcium Transport in Plasma Membrane and Endoplasmic Reticulum from Rat Brain. |
| Author |
Mundy, W. R. ;
Kodavanti, P. R. S. ;
Dulchinos, V. F. ;
Tilson., H. A. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. |
| Publisher |
c1994 |
| Year Published |
1994 |
| Report Number |
EPA/600/J-94/200; |
| Stock Number |
PB94-163797 |
| Additional Subjects |
Aluminum ;
Calcium ;
Biological transport ;
Brain ;
Endoplasmic reticulum ;
Toxicity ;
Reprint ;
Ca(2+) Mg(2+)-ATPase ;
Rats ;
Microsomes ;
Synaptosomes ;
Homeostasis ;
Signal transduction ;
Cell membrane ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB94-163797 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
Calcium is actively transported into intracellular organelles and out of the cytoplasm by Ca(2+)/Mg(2+)-ATPases located in the endoplasmic reticulum and plasma membranes. The authors studied the effects of aluminum on calcium transport in the adult rat brain. They examined (45)Ca-uptake in microsomes and Ca(2+)-ATPase activity in microsomes and synaptosomes isolated from the frontal cortex and cerebellum of adult male Long-Evans rats. ATP-dependent (45)Ca-uptake was similar in microsomes from both brain regions. The addition of 50-800 microM AlCl3 resulted in a concentration-dependent inhibition of (45)Ca-uptake. Mg(2+)-dependent Ca(2+)-ATPase activity was significantly lower in synaptosomes compared to microsomes in both frontal cortex and cerebellum. In contrast to the uptake studies, AlCl3 stimulated Mg(2+)-dependent Ca(2+)-ATPase activity in both microsomes and synaptosomes from both brain regions. To determine the relationship between aluminum and Mg(2+), the authors measured ATPase activity in the presence of increasing concentrations of Mg(2+) or AlCl3. Maximal ATPase activity was obtained between 3 and 6 mM Mg(2+). (Copyright (c) 1994 VCH Publishers, Inc.) |
| Supplementary Notes |
Pub. in Jnl. of Biochemical Toxicology, v9 n1 p17-23 Feb 94. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Aluminum Alters Calcium Transport in Plasma Membrane and Endoplasmic Reticulum from Rat Brain. |
| Category Codes |
57Y; 57B; 57F |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
416823432 |
| Origin |
NTIS |
| Type |
CAT |
