Full Record Display for the EPA National Library Catalog
RECORD NUMBER: 234 OF 1079| Main Title | Drinking Water Criteria Document for Simazine. | |||||||||||
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| CORP Author | Dynamac Corp., Rockville, MD.;Environmental Protection Agency, Washington, DC. Office of Drinking Water. | |||||||||||
| Publisher | May 90 | |||||||||||
| Year Published | 1990 | |||||||||||
| Stock Number | PB90-215344 | |||||||||||
| Additional Subjects | Potable water ; Toxicology ; Water quality ; Herbicides ; Mutagens ; Carcinogens ; Reproduction(Biology) ; Lethal dosage ; Exposure ; Laboratory animals ; Simazine ; Pharmacokinetics ; Water pollution effects(Humans) ; Water pollution effects(Animals) ; Health hazards ; Carcinogenicity tests ; Path of pollutants ; Mutagenicity tests ; Chromosome aberrations | |||||||||||
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| Collation | 85p | |||||||||||
| Abstract | Simazine is the common name for 2-chloro-4,6-bis(ethylamino)-1,3,5 triazine. The acute oral LD50 estimates are 5,000 mg/kg or higher in rats, mice, rabbits, and birds, but a dose of 500 mg/kg has been reported to be lethal in sheep. Pharmacotoxic signs in sheep included incoordination, tremors, weakness, cyanosis, and clonic convulsions. A dose of 4,200 mg/kg caused anorexia, weight loss, and some lethality in rats. In a three-generation reproduction study with Charles River rats fed simazine 80W in the diet at 50 or 100 ppm, a parental toxicity NOAEL of less than 50 ppm and a LOAEL of 50 ppm were identified based on reduced weight gains in males during the premating periods. In a teratology study with rats, simazine administered at high doses (1,250 and 2,500 mg/kg/day) during gestation days 6 through 15 delayed fetal development and was embryotoxic but not teratogenic. Most tests of mutagenic potential for simazine have been negative. | |||||||||||
| Supplementary Notes | Sponsored by Environmental Protection Agency, Washington, DC. Office of Drinking Water. | |||||||||||
| NTIS Title Notes | Draft rept. (Final). | |||||||||||
| Category Codes | 57U; 57Y; 68D | |||||||||||
| NTIS Prices | PC A05/MF A01 | |||||||||||
| Primary Description | 700/03 | |||||||||||
| Document Type | NT | |||||||||||
| Cataloging Source | NTIS/MT | |||||||||||
| Control Number | 022219788 | |||||||||||
| Origin | NTIS | |||||||||||
| Type | CAT |