| Main Title |
Binding of Chemical Carcinogens and Mutagens to Rat Hemoglobin. |
| Author |
Pereira, M. A. ;
Chang, Lina W. ;
|
| CORP Author |
Health Effects Research Lab., Cincinnati, OH. |
| Year Published |
1980 |
| Report Number |
EPA-600/J-81-148; |
| Stock Number |
PB81-212144 |
| Additional Subjects |
Carcinogens ;
Mutagens ;
Binding ;
Hemoglobins ;
Rats ;
Blood proteins ;
Reprints ;
NTISEPAORD
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB81-212144 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
The alkylation of hemoglobin is a proposed dose monitor for chemical carcinogens and mutagens. The binding of fifteen chemical carcinogens and mutagens to rat hemoglobin was determined. Direct acting carcinogens and indirect acting carcinogens including aromatic amines, halogenated hydrocarbons, nitrosamines, polycyclic aromatic hydrocarbons, aflatoxin B1 and benzene bound hemoglobin. The efficiency of carcinogen and mutagen hemoglobin was dose dependent and ranged from 0.007 to 2.3% of an oral dose. The binding of chemical carcinogens and mutagens to hemoglobin would appear to be generic so that it could be developed into a dose monitor for a large number of known carcinogens and mutagens. |
| Supplementary Notes |
Pub. in Chem.-Biol. Interactions 33, p301-305 1981. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Binding of Chemical Carcinogens and Mutagens to Rat Hemoglobin. |
| PUB Date Free Form |
7 Aug 80 |
| Category Codes |
6T; 6A; 57Y; 57B |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323799505 |
| Origin |
NTIS |
| Type |
CAT |
