| Main Title |
Initial Submission: Toxicity Report on 2,2'-(4-Methyl- 6-Tertiary-Butylphenol) with Cover Letter dated 10/15/1992. |
| CORP Author |
Ashland Oil, Inc., KY.; Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
8EHQ-1092-11704 |
| Stock Number |
OTS0571632 |
| Additional Subjects |
Toxicology ;
Health effects ;
2 ;
2'-methylene- bis-(4-methyl- 6-tertiary-butylphenol) ;
Primary dermal sensitization ;
Mammals ;
Humans ;
Dermal ;
Subchronic toxicity ;
Rabbits ;
Rats ;
Inhalation ;
Guinea pigs ;
Dogs ;
Primary eye irritation ;
Acute toxicity ;
Mice ;
Oral ;
Gavage ;
Diet ;
CAS No 119-47-1
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0571632 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
15p |
| Abstract |
The application of a 20% concentration of the Antioxidant in polyethylene glycol under a gauze pad, to the skin of ten man for 98 hours, produced no significant irritation. Subsequent patch tests on fifty adult males using the some concentration, and repeated applications to a site irritated by freezing yielded one case of weak but definite sensitization. It is concluded that dermatitis from this product would be anticipated only in highly susceptible individuals and only after prolonged and severe exposures. The application of a test dose of 0.4 gm./Kg of the Antioxidant as a 10% solution in Wesson Oil to the rabbit skin, and held in contact with the aninals for 18 hours, produced only a slight generalized crythema which vanished in 48 hours. Six doses repeated on alternate days produced progressively severe irritation. At sacrifices and autopsy following the skin applications, no signs of systemic toxicity and no significant gross pathology were observed. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
27 Oct 1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028700810 |
| Origin |
NTIS |
| Type |
CAT |
