| Main Title |
Neuroendocrinology of Female Reproduction: Review, Models, and Potential Approaches for Risk Assessment. |
| Author |
Hess, D. L. ;
|
| CORP Author |
Oregon Regional Primate Research Center, Beaverton. Div. of Reproductive Biology and Behavior.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. |
| Publisher |
c1988 |
| Year Published |
1988 |
| Report Number |
EPA/600/J-88/293; |
| Stock Number |
PB89-202287 |
| Additional Subjects |
Reproduction(Biology) ;
Females ;
Hypothalamus ;
Pituitary gland ;
Toxicology ;
Gonadotropins ;
Pulse generators ;
Reprints ;
Neuroendocrinology ;
Animal models ;
Risk assessment
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-202287 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
The central role of the mammalian hypothalamic-pituitary axis in regulating female reproductive cycles is reviewed. A variety of animal models and techniques that offer increased sensitivity, speed, and flexibility over traditional reproductive toxicologic approaches for short-term testing or screening are discussed, including the pivotal analysis of gonadotrophin releasing hormone (GnRH) pulse generator activity in vivo and in vitro. Other neuroendocrine techniques that require further development, but provide potential approaches to demonstrate specific sites or mechanisms of action for toxic effects on the hypothalamic-pituitary axis are suggested. |
| Supplementary Notes |
Pub. in Reproductive Toxicology, v1 n2 p139-145 1988. Sponsored by Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Neuroendocrinology of Female Reproduction: Review, Models, and Potential Approaches for Risk Assessment. |
| Category Codes |
57E; 57Y; 57D |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/21 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
925821620 |
| Origin |
NTIS |
| Type |
CAT |
