Main Title |
Characterization of Chemical Kindling with the Pesticide Endosulfan. |
Author |
Gilbert, M. E. ;
|
CORP Author |
ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. |
Publisher |
c1992 |
Year Published |
1992 |
Report Number |
EPA-68-02-4450; EPA/600/J-92/199; |
Stock Number |
PB92-189059 |
Additional Subjects |
Kindling(Neurology) ;
Organochlorine insecticides ;
Endosulfan ;
Toxicology ;
GABA ;
Seizures ;
Amygdala ;
Rats ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB92-189059 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
The present report evaluated the chemical kindling properties of endosulfan. Repeated administration (3X/wk for 21 doses) of endosulfan was found to induce behavioral seizures in rats. Low dosages (5 & 10 mg/kg in corn oil, po) that were without overt toxicity in the majority of animals upon acute administration, began to elicit signs of seizure (myoclonic jerks and clonic seizures) upon repetition. Heightened seizure responsiveness was maintained following a 2-week wash out period, arguing against cumulative toxicity as a mechanism for seizure induction. Electrical kindling induced by once daily stimulation of the amygdala beginning approximately 4 weeks after the final dose of endosulfan, and in excess of 2 weeks, after the challenge dose revealed a significant facilitation in kindling rate. Thus, prior treatment with endosulfan promoted the development of kindled seizures in the absence of further dosing. A history of endosulfan treatment failed to affect threshold for inducing an afterdischarge (AD), but equivocal effects upon the development of AD. Pretreatment with a single high dose of endosulfan 2 weeks prior to electrical kindling was without effect upon development of the kindled response. Chemical kindling with endosulfan may result from the interaction of this pesticide with GABA-mediated neurotransmission in the central nervous system. |
Supplementary Notes |
Pub. in Neurotoxicology and Teratology, v14 p151-158 1992. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Characterization of Chemical Kindling with the Pesticide Endosulfan. |
Category Codes |
57Y; 57I; 68E |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
220521601 |
Origin |
NTIS |
Type |
CAT |