| Main Title |
Support: Science of Organic Fluorochemistry and Perfluorooctane Sulfonate; Current Summary of Human Sera, Health and Toxicology Data, with Cover Letter dated 02/05/1999. |
| CORP Author |
Hazleton Labs. America, Inc., Madison, WI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
8EHQ-0299-0373 |
| Stock Number |
OTS0204929-6 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Fluorine ;
Environmental fate ;
Physical/chemical properties ;
Perfluorooctane sulfonate ;
Laboratory animals ;
Reproduction/fertility effects ;
Teratogenicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
CAS No 7782-41-4 ;
CAS No 2795-39-3
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0204929-6 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
258p |
| Abstract |
Potassium perfluorooctane sulfonate (CAS 2795-39-3) was evaluated for development toxicity in female Sprague-Dawley CD rats (25/group)administered doses of 1, 5, mg/kg/day by oral gavage on presumed Gestation Days 6-15. Clinical signs of mate toxicity included emaciation (1, 5, 10 mg/kg/day), hunched posturing (5, 10 mg/k lopecia)(5, 10 mg/kg/day), rough haircoats (5, 10 mg/kg/day), anorexia (10 mg/k mortality)(2/25, 10 mg/kg/day). Both food consumption and bodyweight gain were in mid- and high-dose groups and adjusted terminal bodyweights (minus gravidute weights) were also significantly below those of controls. Gross pathology was lesions of the gastrointestinal tract in 10 mg/kg/day dams. Reproductive effects related fetal loss by resorption and dead fetuses in litters (10 mg/kg/day) and significant (p < 0.05) decreases in male and female fetal bodyweights. Subcutane cleft palate, and cryptorchism characterized the toxicologically significant extravisceral aberrations in fetuses in the 10 mg/kg/day dams. Skeletal ossification delayed in the fetuses of this group as was indicated by significantly increased girdle, rib cage, vertebral column, pelvic girdle, and limb variants. Document includes: Support: Rat Teratology Study T-3351 (with Perfluorooctane Sulfonate), Final Report, with Cover Letter dated 3/15/1999. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
Feb 2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A13/MF A13 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500550 |
| Origin |
NTIS |
| Type |
CAT |
