| Main Title |
Support: Final Report, 3-Generation Reproductive Toxicity Evaluation Bisphenol A Administered in Feed to CD (Sprague-Dawley) Rats, with Cover Letter dated 10/26/2000. |
| CORP Author |
Research Triangle Inst., Research Triangle Park, NC. Center for Life Sciences and Toxicology.; Society of the Plastics Industry, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
8EHQ-1000-13581 |
| Stock Number |
OTS0558455-5 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
4 ;
4'-isopropylidene-2-diphenol ;
Reproduction ;
Fertility effects ;
Teratogenicity ;
Mammals ;
Oral ;
Gavage ;
CAS No 80-05-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0558455-5 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
2622p |
| Abstract |
Male and female Sprague-Dawley derived outbred albino rats were administered Bisphenol A (BPA; CAS No. 80-05-7) in the feed at 0, 0.015, 0.3, 4.5, 75, 750, and 7500 ppm (resulting in BPA intakes of approximately 0.001, 0.02, 0.3, 5, 50, and 500 mg/kg/day, respectively), available ad libitum, 30 animals/sex/dose, for ten weeks. This study was conducted according to the OPPTS Testing Guidelines (870.3800; 1998) with additions (a third generation; seven treatment groups; examination for retained nipples in Fl, F2, and F3 preweanling males; retention of F3 offspring, 30/sex/group, until adulthood with exposures continuing; measuring anogenital distance and acquisition of puberty in both sexes; epididymal sperm and testicular spermatids; estrous cyclicity; and full necropsy and histopathology). Body weights and feed consumption were recorded weekly, and clinical signs were recorded at least once daily. Vaginal cytology was evaluated for the last three weeks of the prebreed period. Animals were then randomly mated within treatment groups for a two-week mating period to produce the F1 generation, with treatment continued throughout breeding. All surviving FO males were necropsied after the F1 delivery period, with histologic evaluation of reproductive and other organs and andrological assessments (reproductive organ weights, epididyntal sperm number, motility and morphology, testicular homogenization-resistant spermatid head counts, daily sperm production, and efficiency of daily sperm production). Fl litters were culled to ten pups on postnatal day (pnd) 4 and weaned on pnd 21. At weaning, up to three weanlings/sex/litter were randomly selected and necropsied with selected organ weights, and 30/sex/dose were randomly selected as F1 parents of the F2 generation. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
26 Oct 2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A99/MF A99 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500080 |
| Origin |
NTIS |
| Type |
CAT |
