| Main Title |
Support: An Inhalation Reproductive Toxicity Study of Octamethylcyclotetrasiloxane (D4) in Female Rats using Multiple Exposure Regimens, with Cover Letter dated 06/01/1998. |
| CORP Author |
Dow Corning Corp., Midlands, MI. Health and Environmental Sciences Dept.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1998 |
| Report Number |
8EHQ-0698-13585 |
| Stock Number |
OTS0558459-3 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Octamethylcyclotetrasiloxane ;
Reproduction ;
Fertility effects ;
Combined teratogenicity ;
Reproductive effects ;
Mammals ;
Rats ;
Inhalation ;
CAS No 556-67-2
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0558459-3 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
1112p |
| Abstract |
In several earlier single generation reproductive toxicity studies, rats were exposed to high concentrations of octamethyleyclotetrasiloxane (OMCTS) for a prolonged premating interval (28 - 70 consecutive days). Exposures continued during the mating period, throughout gestation, and (in some studies) during lactation. In the earlier studies, decreased litter sizes. decreased numbers of uterine implantations. and reduced numbers of corpora lutea were seen; these findings were previously communicated to EPA. This study was conducted to help identify the sensitive interval and reproductive events affected in female rats exposed to OMCTS by whole body vapor inhalation. Female rats were exposed for six hours daily to the test article at different times during their reproductive cycles as noted below. Lapohyster- ectomies were performed on gestation day 20, and corpora lutea and uterine contents were evaluated. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
4 Jun 1998 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A99/MF A99 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500110 |
| Origin |
NTIS |
| Type |
CAT |
