| Main Title |
Support: An Inhalation Range-Finding Reproductive Toxicity Study of Octamethylcyclotetrasiloxane (D4) in Male Rats with Cover Letter dated 12/03/1997. |
| CORP Author |
Dow Corning Corp., Midlands, MI. Health and Environmental Sciences Dept.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1998 |
| Report Number |
8EHQ-1297-13585 |
| Stock Number |
OTS0558459-2 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Octamethylcyclotetrasiloxane ;
Reproduction ;
Fertility effects ;
Combined teratogenicity ;
Reproductive effects ;
Mammals ;
Rats ;
Inhalation ;
CAS No 556-67-2
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0558459-2 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
1384p |
| Abstract |
As a supplemental submission to our earlier TSCA Section 8(e) notifications of July 2, 1996 and December 20, 1996, Dow Corning is submitting the final reports for two range-finding inhalation reproductive toxicity studies in which male.rats were exposed to octamethylcyclotetrasitoxane (OMCTS, 94). In the first study, slight decreases (statistically insignificant) in pup viability and statistically significant reductions in FI pup weights were noted in offspring otmale rats from the high exposure group (700 ppm). A second study of similar design but of greater statistical power failed to detect any indication of adverse effects in pups sired by male similarly exposed to OMCTS. We conclude that OMCTS does not cause adverse effects in the offspring of male rats exposed to OMCTS. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2 Jan 1998 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A99/MF A99 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500100 |
| Origin |
NTIS |
| Type |
CAT |
