| Main Title |
Initial Submission: Teratological Evaluation of Inhaled Acrylonitril Monomer in Rats with Cover Letter dated 09/01/1992. |
| CORP Author |
Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
8EHQ-0892-10275 |
| Stock Number |
OTS0570857 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Acrylonitril monomer ;
Reproduction ;
Fertility effects ;
Teratogenicity ;
Mammals ;
Rats ;
Inhalation ;
CAS No 107-13-1
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0570857 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
52p |
| Abstract |
Pregnant Sprague-Dawley rats were exposed to 0, 40, or 80 ppm of acrylonitrile by inhalation for 6 hrs per day from days 6 through 15 of gestation. Inhalation of 80 ppm, a maternally and embryonally toxic concentration, did not significantly alter the incidence of any single malformation. The incidence of total malformations, when considered col- lectively, was marginally increased (p=0.06) at 80 ppm. Also noted at 80 ppm was a low incidence of the same mal- formations seen in an earlier study in which pregnant rats were given acrylonitrile by gavage. At 40 ppm, significant maternal toxicity was evident, but no signs of embryotoxicity, fetotoxicity, or teratogenicity were seen. In conclusion, findings suggestive of a teratogenic effect were seen in the offspring of pregnant rats inhaling 80 ppm but not 40 ppm of acrylonitrile. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
31 Aug 1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A05/MF A05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
018800220 |
| Origin |
NTIS |
| Type |
CAT |
