| Main Title |
Initial Submission: Teratological Dose Range-finding Study with N-methylpyrrolidone in Sprague-dawley Rats (Final Report) with Attachments and Cover Letter Dated 02/27/1992. |
| CORP Author |
Food and Drug Research Labs., Inc., Waverly, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
88-920001293 |
| Stock Number |
OTS0535882 |
| Additional Subjects |
Toxicology ;
Health effects ;
N-methylpyrrolidone ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rats ;
Dermal ;
Toxic substances ;
Laboratory animals ;
CAS No 872-50-4
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0535882 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
69p |
| Abstract |
N-Methylpyrrolidone (872-50-4) was evaluated in a dose range-finding teratology study in which groups of 5 female Sprague-Dawley rats were administered the test substance dermally applied to the back at 0, 0.5, 1.1, or 2.5 g/kg/day on days 6 through 15 of gestation. Animals were sacrificed on da 20 of gestation. Animals in all test levels had dry patches of skin on the backs and showed bright yellow urine. Four out of 5 animals at the 2.5 g/kg/day group died. Maternal body weight gain was decreased at 1.1 g/kg/day but was not affected at 0.5 g/kg/day. At 1.1 g/kg/day 65/66 fetuses were resorbed (the single surviving fetus wassignificantly smaller than control fetuses). There was no effects on pregnancy, implantation, or gestation in the 0.5 g/kg/day group when compared with controls. None of the fetuses from treated dams at any level exhibited external abnormalities or malformations. Significance was judged at a probability level of 0.05 in all cases. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A05/MF A05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803440 |
| Origin |
NTIS |
| Type |
CAT |
