| Main Title |
DNA-Benzo(a)Pyrene Adducts Formed in a 'Salmonella typbimurium' Mutagenesis Assay System. |
| Author |
Santella, Regina M. ;
Grunberger, Dezider ;
Weinstein, I. Bernard ;
|
| CORP Author |
Columbia Univ., New York. Coll. of Physicians and Surgeons.;Health Effects Research Lab., Research Triangle Park, NC.;National Cancer Inst., Bethesda, MD. |
| Year Published |
1979 |
| Report Number |
R-805482 ;PHS-CA-13696; EPA-600/J-79-147; |
| Stock Number |
PB83-145300 |
| Additional Subjects |
Deoxyribonucleic acid ;
Bacteria ;
Bioassay ;
Incubation ;
Enzymes ;
Reprints ;
Salmonella typhimurium ;
Benzopyrene ;
Mutagenesis
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB83-145300 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
The DNA adducts formed in Salmonella typhimurium when bacteria are incubated with radioactive benzo(a)pyrene and liver microsomal enzymes from several sources has been investigated. When enzyme prepartions from Aroclor 1254 or 3-methylcholanthrene induced C57BL/6N (B6) mice were used to mediate activation, the predominant product was n adduct between the 10 position of 7B,8a-dihydroxy-9a,10a epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene and the N-2 position of deoxyguanosine. Similar results were obtained with human liver and with Aroclor-induced rat-liver enzyme preparations. |
| Supplementary Notes |
Pub. in Mutation Research, v61 p181-189 1979. Sponsored in part by Grant PHS-CA-21111. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: DNA-Benzo(a)Pyrene Adducts Formed in a 'Salmonella typbimurium' Mutagenesis Assay System. |
| PUB Date Free Form |
9 Mar 79 |
| Category Codes |
6A; 57B |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
305048137 |
| Origin |
NTIS |
| Type |
CAT |
