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Main Title Proconvulsant Activity of Endosulfan in Amygdala Kindling.
Author Gilbert, M. E. ;
CORP Author ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/194;
Stock Number PB92-189000
Additional Subjects Kindling(Neurology) ; Seizures ; Endosulfan ; Amygdala ; Organochlorine insecticides ; Toxicology ; Dose-response relationships ; GABA ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB92-189000 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Abstract The proconvulsant properties of the chlorinated hydrocarbon insecticide, endosulfan, were investigated using electrical kindling of the amygdala. Male rats were implanted with electrodes in the amygdala and stimulated once daily with a standard kindling stimulus 60-90 min following endosulfan (0, 2.5, 5.0 mg/kg, PO). No alterations were observed in either the threshold to induce an afterdischarge (AD) or the duration of clonus upon seizure generalization. Endosulfan significantly reduced the number of stimulations required to produce Stage 5 generalized seizures. Seizures prior to stimulation were evident in a subset of animals from both dosage groups and were never observed in controls. The presence of kindled seizures was maintained in the absence of further dosing, as amygdala stimulation 2-4 weeks after the last endosulfan treatment resulted in generalized seizures in all animals. The results suggest that faster kindling rates induced by endosulfan are not readily attributable to transient toxicant-related increases in excitability of the nervous system. It was concluded that endosulfan has proconvulsant properties that may be related to an action on GABA within the central nervous system. (Copyright (c) 1992 Pergamon Press Ltd.)
Supplementary Notes Pub. in Jnl. of Neurotoxicology and Teratology, v14 p143-149 1992. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
NTIS Title Notes Journal article.
Title Annotations Reprint: Proconvulsant Activity of Endosulfan in Amygdala Kindling.
Category Codes 57Y; 57I; 68E
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 220521558
Origin NTIS
Type CAT