Full Record Display for the EPA National Library Catalog

RECORD NUMBER: 2 OF 4

OLS Field Name OLS Field Data
Main Title Induction, Accumulation, and Persistence of Sister Chromatid Exchanges in Women with Breast Cancer Receiving Cyclophosphamide, Adriamycin, and 5-Fluorouracil Chemotherapy.
Author Tucker, J. D. ; Wyrobek, A. J. ; Ashworth, L. K. ; Christensen, M. L. ; Burton., G. V. ;
CORP Author Lawrence Livermore National Lab., CA. Biomedical Sciences Div. ;Duke Univ. Medical Center, Durham, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. Epidemiology Branch.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/240;
Stock Number PB91-116988
Additional Subjects Antineoplastic agents ; Breast neoplasma ; Cyclophosphamide ; Fluorouracil ; Mutagens ; Lymphocytes ; Reprints ; Sister chromatid exchange ; Doxorubicin ; Intravenous infusions
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB91-116988 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/04/1991
Collation 8p
Abstract The induction, stimulation, and persistence of sister chromatid exchanges (SCE's) and high SCE frequency cells (HFC's) was measured in peripheral lymphocytes of women with breast cancer before chemotherapy and on multiple occasions during and after therapy. Chemotherapy consisted of i.v. infusion of cyclophosphamide, Adriamycin, and 5-fluorouracil, administered on day 1 of each of approximately six 21-day cycles. This treatment resulted in a highly significant of SCE's (1.8-fold, P < 0.0001) and HFC's (5-fold, P < 0.0001) measured in samples obtained 1 week after the first therapy. Accumulation of lesions leading to SCE's was measured by comparing samples surrounding the first and last rounds of therapy and was significant for both SCE's and HFC's in most comparisons. Persistence of lesions leading to SCE's was evaluated at multiple times until 9 months after completion of therapy, and both SCE's and HFC's remained significantly elevated throughout this time.
Supplementary Notes Pub. in Cancer Research, v50 p4951-4956, 15 Aug 90. Prepared in cooperation with Duke Univ. Medical Center, Durham, NC., and National Inst. of Environmental Health Sciences, Research Triangle Park, NC. Epidemiology Branch. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Induction, Accumulation, and Persistence of Sister Chromatid Exchanges in Women with Breast Cancer Receiving Cyclophosphamide, Adriamycin, and 5-Fluorouracil Chemotherapy.
Category Codes 57E; 57Q; 57F
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 101123794
Origin NTIS
Type CAT