| Main Title |
Differential Susceptibility of Immature Rat Testes to Doxorubicin at Critical States of Maturation. |
| Author |
Bechter, R. ;
Haebler, R. ;
Ettlin, R. A. ;
Haseman, J. K. ;
Dixon, R. L. ;
|
| CORP Author |
National Inst. of Environmental Health Sciences, Research Triangle Park, NC. ;Michigan State Univ., East Lansing.;Environmental Research Lab., Narragansett, RI. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/343; |
| Stock Number |
PB88-202080 |
| Additional Subjects |
Toxicology ;
Reproduction(Biology) ;
Toxicity ;
Laboratory animals ;
Reproductive systems ;
Fertility ;
Doxorubicin
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-202080 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
The toxic effects of doxorubicin on the reproductive system of the male rate were studied at different susceptible stages of postnatal development. A multidisciplinary approach including the assessment of histopathological, functional, and biochemical parameters was chosen. Groups of male rats were treated once with the compound (3 mg/kg) on postnatal day 6, 16, 24 or 45. Initial toxicity was observed in the group treated at 24 days of age; particularly, low reproductive organ weights and low sperm counts were found. These findings proved reversible towards the end of the study. Neither biochemical nor functional impairment of the reproductive system could be observed in the group treated at 45 days of age. (Copyright (c) Springer-Verlag, 1987.) |
| Supplementary Notes |
Pub. in Archives of Toxicology, v60 p415-421 1987. Prepared in cooperation with Michigan State Univ., East Lansing. Sponsored by Environmental Research Lab., Narragansett, RI. |
| NTIS Title Notes |
Journal article. |
| PUB Date Free Form |
c1987 |
| Category Codes |
57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
819623331 |
| Origin |
NTIS |
| Type |
CAT |
