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OLS Field Name OLS Field Data
Main Title Differential Susceptibility of Immature Rat Testes to Doxorubicin at Critical States of Maturation.
Author Bechter, R. ; Haebler, R. ; Ettlin, R. A. ; Haseman, J. K. ; Dixon, R. L. ;
CORP Author National Inst. of Environmental Health Sciences, Research Triangle Park, NC. ;Michigan State Univ., East Lansing.;Environmental Research Lab., Narragansett, RI.
Year Published 1987
Report Number EPA/600/J-87/343;
Stock Number PB88-202080
Additional Subjects Toxicology ; Reproduction(Biology) ; Toxicity ; Laboratory animals ; Reproductive systems ; Fertility ; Doxorubicin
Library Call Number Additional Info Location Last
NTIS  PB88-202080 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 09/04/1988
Collation 9p
Abstract The toxic effects of doxorubicin on the reproductive system of the male rate were studied at different susceptible stages of postnatal development. A multidisciplinary approach including the assessment of histopathological, functional, and biochemical parameters was chosen. Groups of male rats were treated once with the compound (3 mg/kg) on postnatal day 6, 16, 24 or 45. Initial toxicity was observed in the group treated at 24 days of age; particularly, low reproductive organ weights and low sperm counts were found. These findings proved reversible towards the end of the study. Neither biochemical nor functional impairment of the reproductive system could be observed in the group treated at 45 days of age. (Copyright (c) Springer-Verlag, 1987.)
Supplementary Notes Pub. in Archives of Toxicology, v60 p415-421 1987. Prepared in cooperation with Michigan State Univ., East Lansing. Sponsored by Environmental Research Lab., Narragansett, RI.
NTIS Title Notes Journal article.
PUB Date Free Form c1987
Category Codes 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/05
Document Type NT
Cataloging Source NTIS/MT
Control Number 819623331
Origin NTIS
Type CAT