| Main Title |
Dose-Response Relationships in Mice Following Subchronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin: CYP1A1, CYP1A2, Estrogen Receptor, and Protein Tyrosine Phosphorylation. |
| Author |
DeVito, M. J. ;
Ma, X. ;
Babish, J. G. ;
Menache, M. ;
Birnbaum., L. S. ;
|
| CORP Author |
North Carolina Univ. at Chapel Hill. Center for Environmental Medicine and Lung Biology. ;Paracelsian, Inc., Ithaca, NY. Cellular Physiology Section. ;New York State Coll. of Veterinary Medicine, Ithaca. ;Duke Univ. Medical Center, Durham, NC. Center for Extrapolation Modelling.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. |
| Publisher |
c1994 |
| Year Published |
1994 |
| Report Number |
EPA-R-817643 ;EPA-R-813113; EPA/600/J-94/196; |
| Stock Number |
PB94-163755 |
| Additional Subjects |
Tetrachlorodibenzodioxin ;
Toxicity ;
Cytochrome P-450 ;
Estrogen receptors ;
Tyrosine ;
Dose-response relationships ;
Phosphorylation ;
Liver ;
Lung ;
Skin(Anatomy) ;
Reprint ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB94-163755 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
The dose-response relationships for different endpoints in different tissues were compared in response to 2,3,7,8-tetrachlorodibenzodioxin (TCDD) treatment. TCDD was administered 5 days/week for 13 weeks at doses ranging from 1.5 - 150 ng/kg/day to female B6C3F1 mice. Ethoxyresorufin-O-deethylase (EROD) activity was increased in liver, lung and skin at doses as low as 1.5 ng/kg/day. EROD activity did not attain maximal induction. Liver acetanilide-4-hydroxylase activity was induced at doses as low as 1.5 ng/kg/d and reached maximal induction at 45 ng/kg/d. TCDD treatment significantly increased the amount of three phosphotyrosyl proteins in liver S-20 fractions. Changes in phosphotyrosyl proteins reached maximal induction at 4.5 ng/kg/d. Hepatic and uterine estrogen receptor levels were unchanged at any of the doses tested. These data indicate that TCDD produces multiple effects with multiple dose-response curves suggesting that there are events in addition to receptor binding that are endpoint-specific, leading to different dose-response relationships. |
| Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology v124 n1 p82-90 Jan 94. Prepared in cooperation with Paracelsian, Inc., Ithaca, NY. Cellular Physiology Section., New York State Coll. of Veterinary Medicine, Ithaca., and Duke Univ. Medical Center, Durham, NC. Center for Extrapolation Modelling. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Dose-Response Relationships in Mice Following Subchronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin: CYP1A1, CYP1A2, Estrogen Receptor, and Protein Tyrosine Phosphorylation. |
| Category Codes |
57Y; 57F; 57B |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
416823405 |
| Origin |
NTIS |
| Type |
CAT |
