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Main Title Dopamine Depletion Slows Retinal Transmission.
Author Dyer, Robert S. ; Howell, William E. ; MacPhail, Robert C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA-600/J-80-014;
Stock Number PB82-127432
Additional Subjects Norepinephrine ; Eye(Anatomy) ; Retina ; Depletion ; Reprints ; Dopamine
Library Call Number Additional Info Location Last
NTIS  PB82-127432 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 17p
Abstract In male hooded rats, depletion of norepinephrine and dopamine by a-methyl-paratyrosine (AMT) significantly increased the latencies of early peaks in flash-evoked potentials recorded from the visual cortex, lateral geniculate nucleus, and optic tract. These effects were not produced by depletion of norepinephrine by FLA-63, blockade of muscarinic acetylcholine receptors by scopolamine, or blockade of opiate receptors by naloxone. AMT effects occurred only when flashes were used; optic tract stimulation failed to reveal the drug-induced changes. In a dose-response study, haloperidol produced effects similar to those of AMT. L-Dopa + R04-4602 reversed some of the effects of AMT. It is concluded that depletion of retinal dopamine impairs the timing of retinal responses to light.
Supplementary Notes Pub. in Experimental Neurology 71, p326-340 1981.
NTIS Title Notes Journal article.
Title Annotations Reprint: Dopamine Depletion Slows Retinal Transmission.
PUB Date Free Form Sep 81
Category Codes 6P; 57S
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 323807662
Origin NTIS
Type CAT