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Main Title Effects of manganese and their modification by hexametaphosphate /
Author Bull, Richard J.
CORP Author Health Effects Research Lab., Cincinnati, Ohio. Water Quality Div.
Publisher Health Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency,
Year Published 1977
Report Number EPA/600/1-77/024
Stock Number PB-272 264
OCLC Number 14697614
Subjects Manganese ; Trace elements in animal nutrition ; Trace elements in annimal nutrition
Additional Subjects Manganese ; Toxicity ; Dopamine ; Ingestion(Biology) ; Dosage ; Rats ; Laboratory animals ; Experimental data ; Potable water ; Water supply ; Recommendations ; Toxicology ; Water treatment ; Physiological effects ; Exposure ; Nervous system disorders ; Tables(Data) ; Standards ; Inorganic phosphates ; Environmental health ; Water pollution effects(Humans) ; Maximum permissible exposure level ; Threshold limit values ; Occupational safety and health ; Toxic tolerances ; Metaphosphoric acid
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 600-1-77-024 c.1 Headquarters Library/Washington,DC 04/14/2014
EKCD  EPA-600/1-77-024 CEMM/GEMMD Library/Gulf Breeze,FL 05/29/2018
ELBD ARCHIVE EPA-600-1-77-024 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ELBD  EPA 600-1-77-024 AWBERC Library/Cincinnati,OH 09/02/2016
NTIS  PB-272 264 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 20 pages ; 28 cm
Abstract The ability of oral Mn(+2) to produce the depletions of dopamine in the corpus striata characteristic of the Parkinson-like syndrome in manganese workers was examined in rats. A second objective of this work was to study the biological interactions between Mn(+2) and sodium hexametaphosphate ((NaPO3)6) administered simultaneously in drinking water. The authors conclude that Mn(+2) in drinking water presents little hazard in terms of central nervous system involvement in a homogeneous population. The involvement of genetic factors which have been suggested to account for the sporadic occurrence of Parkinson-like symptoms in Mn(+2) workers can not be excluded. The use of (NaPO3)6 for Mn(+2) complexation as an alternative to removal in drinking water treatment appears safe from a health standpoint if carefully controlled to avoid excessive amounts of (NaPO3)6.
Notes "May 1977."
Place Published Cincinnati, Ohio
Corporate Au Added Ent Health Effects Research Laboratory (Cincinnati, Ohio)
Title Ser Add Ent Research reporting series. Environmental health effects research.
PUB Date Free Form 1977
Series Title Traced Environmental Health Effects Research Series.
Series Title Untraced Environmental Health Effects Research series
NTIS Prices PC A03/MF A01
BIB Level m
Medium unmediated
Content text
Carrier volume
Cataloging Source OCLC/T
OCLC Time Stamp 20180523082515
Language eng
Origin OCLC
OCLC Rec Leader 01648cam 2200433Ka 45010