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Main Title Is 1,4-Dioxane a Genotoxic Carcinogen.
Author Kitchin, K. T. ; Brown, J. L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Publisher cAug 90
Year Published 1990
Report Number EPA/600/J-90/427;
Stock Number PB91-171827
Additional Subjects Dioxanes ; Mutagens ; Carcinogens ; Toxicology ; Mutagenicity tests ; Carcinogenicity tests ; Dose-response relationships ; Biochemistry ; DNA damage ; Liver ; Cytochrome P-450 ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB91-171827 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
Abstract Linear models of risk assessment may be appropriate for chemical that are initiators of carcinogenesis while threshold model of risk assessment have been proposed for promoters. The proper risk assessment model for the regulation of promoters of carcinogenesis remains an active area of research and controversy. Cancer is a multistage process (e.g. initiation, promotion and prograssion). These three stages of the oncogenic process have different biological characteristics. Studies to determine which chemicals effects which stages and to what degree are needed for risk assessment. The in-vivo biochemical system described in the report can be performed in a species specific and organ specific manner. In the report 1,4-dioxane is given to rats at doses of 168, 840, 2550, or 4200 mg/kg. DNA damage occurred at 2550 and 4200 mg/kg. This is the first description of genotoxicity of 1,4-dioxane in-vivo. Hepatic ornithine decarboxylase activity was also induced by 1,4-dioxane. This 1,4-dioxane appears to be a weak genotoxics carcinogen and a strong nongenotoxic carcinogen.
Supplementary Notes Pub. in Cancer Letters, v53 n1 p67-71 Aug 90.
NTIS Title Notes Journal article.
Title Annotations Reprint: Is 1,4-Dioxane a Genotoxic Carcinogen.
Category Codes 57Y; 57F; 68G
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 114324865
Origin NTIS
Type CAT