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Main Title Incorporating Cell Proliferation in Quantitative Cancer Risk Assessment: Approaches, Issues, and Uncertainties.
Author Chen, C. ; Farland, W. ;
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher Feb 90
Year Published 1990
Report Number OHEA-C-359 ;EPA/600/D-90/148;
Stock Number PB90-263146
Additional Subjects Cell division ; Carcinogens ; Dinitrotoluene ; Carcinogenesis ; Risk assessment ; Cultured tumor cells ; Dose-response relationships
Library Call Number Additional Info Location Last
NTIS  PB90-263146 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 45p
Abstract A two-stage tumor growth model that explicitly incorporates mitotic rate of initiated cells is developed. As an example, the model is applied to data from dinitrotoluene (DNT) studies to demonstrate how information on preneoplastic and neoplastic lesions can be incorporated into the dose-response model, to critically examine its implication for quantitative risk assessment, and to simulate issues, problems, and data gaps that may arise when one attempts to incorporate cell proliferation into the quantitative risk estimation.
Supplementary Notes Presented at a Symposium on Chemically Induced Cell Proliferation: Implications for Risk Assessment, Austin, Texas, November 29-December 2, 1989.
NTIS Title Notes Symposium paper (Final).
Category Codes 57Y; 57F; 57E
NTIS Prices PC A03/MF A01
Primary Description 600/21
Document Type NT
Cataloging Source NTIS/MT
Control Number 028532071
Origin NTIS
Type CAT