| Main Title |
Incorporating Cell Proliferation in Quantitative Cancer Risk Assessment: Approaches, Issues, and Uncertainties. |
| Author |
Chen, C. ;
Farland, W. ;
|
| CORP Author |
Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. |
| Publisher |
Feb 90 |
| Year Published |
1990 |
| Report Number |
OHEA-C-359 ;EPA/600/D-90/148; |
| Stock Number |
PB90-263146 |
| Additional Subjects |
Cell division ;
Carcinogens ;
Dinitrotoluene ;
Carcinogenesis ;
Risk assessment ;
Cultured tumor cells ;
Dose-response relationships
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-263146 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
45p |
| Abstract |
A two-stage tumor growth model that explicitly incorporates mitotic rate of initiated cells is developed. As an example, the model is applied to data from dinitrotoluene (DNT) studies to demonstrate how information on preneoplastic and neoplastic lesions can be incorporated into the dose-response model, to critically examine its implication for quantitative risk assessment, and to simulate issues, problems, and data gaps that may arise when one attempts to incorporate cell proliferation into the quantitative risk estimation. |
| Supplementary Notes |
Presented at a Symposium on Chemically Induced Cell Proliferation: Implications for Risk Assessment, Austin, Texas, November 29-December 2, 1989. |
| NTIS Title Notes |
Symposium paper (Final). |
| Category Codes |
57Y; 57F; 57E |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/21 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028532071 |
| Origin |
NTIS |
| Type |
CAT |
