| Main Title |
Subchronic in vivo Cytogenetics Assay in Rats using Nose-Only Inhalation Exposure. Draft Report with Attachments and Cover Letter dated 03/15/90. |
| CORP Author |
Microbiological Associates, Bethesda, MD. ;American Petroleum Inst., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
27 Feb 1990 |
| Year Published |
1990 |
| Report Number |
FYI-OTS-0390-0747; |
| Stock Number |
OTS-0000747 |
| Additional Subjects |
Rats ;
Inhalation ;
Hexane ;
Assays ;
Bone marrow cells ;
Chromosome aberrations ;
Subchronic in vivo cytogenetics assay ;
Sprague-Dawley rats ;
Metaphase cells ;
Colcemid treatment
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000747 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
47p |
| Abstract |
Male and female Sprague-Dawley rats were exposed nose-only for six hours per day for five consecutive days to commercial hexane at concentrations of 876, 3249 and 8715 ppm. Bone marrow cells, arrested in metaphase by colcemid treatment, were collected at 6 and 24 hours from the midpoint of the last exposure. Metaphase cells were examined microscopically for chromosome aberrations. No statistically significant increases in percentage of aberrant cells were observed in the commercial hexane-exposed animals, regardless of exposure concentration or bone marrow harvest time. The results of the assay indicate that under the conditions described in this report, commercial hexane did not induce chromosomal aberrations in bone marrow cells of male or female rats following inhalation exposure for five consecutive days. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| Category Codes |
57 |
| NTIS Prices |
PC A04/MF A01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019103590 |
| Origin |
NTIS |
| Type |
CAT |
