Main Title |
Chemical Interactions among Chlorohydrocarbon Mixtures Found in Wastewater Effluents. |
Author |
Merrick, B. A. ;
Stober, J. A. ;
Condie, L. W. ;
|
CORP Author |
Health Effects Research Lab., Cincinnati, OH. Toxicology and Microbiology Div. |
Year Published |
1988 |
Report Number |
EPA/600/D-88/150; |
Stock Number |
PB88-238456 |
Additional Subjects |
Chlorohydrocarbons ;
Water pollution ;
Chloroform ;
Carbon tetrachloride ;
Rats ;
Pathophysiology ;
Chemical reactions ;
Toxicity ;
Waste water ;
Drinking water
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB88-238456 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
22p |
Abstract |
Various chlorohydrocarbons found in industrial waste effluents, including chloroform (CHC13) and carbon tetrachloride (CCl4), can eventually contaminate public drinking water supplies. The present study was designed to evaluate the interaction between orally administered CHCl3 and CCl4 at hepatic and renal toxic threshold doses in male, Sprague Dawley rats. CHCl3 was administered by oral gavage once daily for 3 days Prior to sacrifice at 0, 0.1, 0.5 and 1.0 mmole/kg/day by itself or in combination with CCl4 at 0.1, 0.5 and 1.0 mmole/kg (administered by oral gavage 16 hr prior to sacrifice). The severity and frequency of hepatocellular damage increased in a dose-related manner with CCl4 and to a lesser extent with CHCl3 when they were administered individually. Renal damage was most evident in the highest CHCl3 dose group. Histopathology and serum enzyme data indicated that hepato-toxicity was greater than additive when CCl4 and CHCl3 were given in combination. |
PUB Date Free Form |
Aug 88 |
Category Codes |
68D; 68G |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
829120819 |
Origin |
NTIS |
Type |
CAT |