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Main Title Sequential Sampling of Plasma Cholinesterase in Mallards ('Anas platyrhynchos') as an Indicator of Exposure to Cholinesterase Inhibitors.
Author Fairbrother, A. ; Bennett, R. S. ; Bennett, J. K. ;
CORP Author Corvallis Environmental Research Lab., OR. ;Northrop Services, Inc., Corvallis, OR.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/106;
Stock Number PB90-108259
Additional Subjects Cholinesterase inhibitors ; Pesticides ; Sequential sampling ; Ducks ; Cholinesterase ; Blood chemical analysis ; Chemical indicators ; Experimental design ; Animal behavior ; Brain ; Toxicity ; Reprints ; Anas platyrhynchos ; Organophosphorus compounds ; Methyl parathion
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NTIS  PB90-108259 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Abstract The use of sequential measurements of plasma cholinesterase (ChE) activity for monitoring exposure to organophosphorus pesticides was investigated in the mallard (Anas platyrhynchos). At the onset of incubation, birds were assigned to treated (400 ppm methyl parathion in the diet), pair-fed (same daily food allotment on a g/kg/d basis as consumed by the treated bird of the pair), control or nonincubating control groups. Blood samples were collected weekly during egg-laying and every 3 days during incubation periods. Both plasma and brain samples were taken on day 24 of incubation. Plasma ChE was more variable than brain ChE among the birds and there were no significant correlations (p>0.05) between plasma and brain samples within treatment groups. Reduced food consumption during incubation did not affect plasma ChE activity (p=0.77). Birds that abandoned their nests had significantly increased (paired t=-2.39, d.f.=9, p<0.05) ChE activity at the time of abandonment. There were significant differences (p<0.01) ion plasma ChE activity between untreated birds, but within-bird variation was 2 and 11 times less than between-bird variation during egg-laying and incubation, respectively. Methyl parathion significantly (p<0.0001) reduced plasma ChE activity. Measurement of plasma ChE activity provides a noninvasive, nonlethal technique for assessing the exposure of animals to ChE inhibitors.
Supplementary Notes Pub. in Environmental Toxicology and Chemistry, v8 p117-122 1989. Prepared in cooperation with Northrop Services, Inc., Corvallis, OR.
NTIS Title Notes Journal article.
Title Annotations Reprint: Sequential Sampling of Plasma Cholinesterase in Mallards ('Anas platyrhynchos') as an Indicator of Exposure to Cholinesterase Inhibitors.
Category Codes 57Y; 68E; 68G
NTIS Prices PC A02/MF A01
Primary Description 600/02
Document Type NT
Cataloging Source NTIS/MT
Control Number 932620923
Origin NTIS
Type CAT