Main Title |
7,12-Dimethylbenz(a)anthracene-DNA Adducts in Sprague-Dawley and Long-Evans Female Rats: The Relationship of DNA Adducts to Mammary Cancer. |
Author |
Daniel, F. B. ;
Joyce, N. J. ;
|
CORP Author |
Health Effects Research Lab., Cincinnati, OH. ;National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Biomedical and Behavioral Science. |
Year Published |
1984 |
Report Number |
EPA/600/J-84/114; |
Stock Number |
PB85-108728 |
Additional Subjects |
Breast carcinoma ;
Deoxyribonucleic acid ;
Rats ;
Females ;
Reprints ;
Anthracene/dimethylbenz ;
Cancer
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB85-108728 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
8p |
Abstract |
7,12-dimethylbenz(a)anthracene (DMBA) is a powerful carcinogen to the mammary gland of the pubescent female Sprague-Dawley (S.D.) rat but is a much less potent inducer of mammary adenocarcinoma in the female Long-Evans (L.E.) rat of the same age. The livers of both strains are refractory to DMBA. The maximum levels of DMBA-DNA adducts formed, in both the mammary gland and liver following intraperitoneal (i.p.) administration of (3H)DMBA (21 micromoles) were significantly higher (p < 0.01) in the resistant, L.E. strain than the sensitive S.D. strain. Maximal levels of DMBA-DNA adducts were observed at 48 hr post administration of the hydrocarbon for both organs of both strains. For the S.D. animals no significant loss of adducts (relative to the 48 hr maxima) was observed from either organ at the last time point (336 hr). In contrast both organs of the L.E. strain showed some evidence of adduct removal. |
Supplementary Notes |
Prepared in cooperation with National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Biomedical and Behavioral Science. |
Availability Notes |
Pub. in Carcinogenesis, v5 n8 p1021-1026 1984. |
NTIS Title Notes |
Rept. for Aug 80-Mar 84. |
Title Annotations |
Reprint: 7,12-Dimethylbenz(a)anthracene-DNA Adducts in Sprague-Dawley and Long-Evans Female Rats: The Relationship of DNA Adducts to Mammary Cancer. |
PUB Date Free Form |
c1984 |
Category Codes |
6T; 6E; 57Y; 57O |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
501823887 |
Origin |
NTIS |
Type |
CAT |