Main Title |
Mutagenicity and carcinogenicity assessment of 1,3-butadiene. |
Author |
Bayard, S. ;
Beliles, R. P. ;
Chiu, A. ;
Gibb, H. J. ;
Sadler, B.
|
CORP Author |
United States. Environmental Protection Agency. Office of Health and Environmental Assessment. |
Publisher |
Office of Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, |
Year Published |
1985 |
Report Number |
EPA-600/8-85-004 F; EPA-600/8-85-004 A |
Stock Number |
PB86-125507; PB85-181097 |
OCLC Number |
12960165 |
Subjects |
Butadiene--Toxicology ;
Carcinogens ;
Mutagens ;
Environmental health
|
Additional Subjects |
Butadiene--Toxicology ;
Carcinogens ;
Mutagens ;
Environmental health ;
Environmental surveys ;
Industrial medicine ;
Rubber industry ;
Laboratory animals ;
Exposure ;
Toxicity ;
Inspection ;
Hazardous materials ;
Air pollution ;
Risk ;
Butadienes ;
Chemical analysis ;
Styrene butadiene resin ;
Ventilation ;
Assessments ;
Dosage ;
Bacteria ;
In vivo analysis ;
Toxic substances ;
Occupational safety and health ;
Indoor air pollution ;
Salmonella typhimurium ;
Styrene butadiene resins
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EHAM |
RA1247.B8 EPA-600 8-85 -004F |
|
Region 1 Library/Boston,MA |
04/29/2016 |
EJBD |
EPA-600/8-85-004A |
|
Headquarters Library/Washington,DC |
02/28/2007 |
EJED |
EPA 600/8-85-004A |
|
OCSPP Chemical Library/Washington,DC |
06/14/2002 |
EKBD |
EPA-600/8-85-004A |
|
Research Triangle Park Library/RTP, NC |
04/16/2004 |
EKBD |
EPA-600/8-85-004F |
c.1 |
Research Triangle Park Library/RTP, NC |
08/23/2016 |
EKBD |
EPA-600/8-85-004F |
c.2 |
Research Triangle Park Library/RTP, NC |
08/23/2016 |
ELBD ARCHIVE |
EPA 600-8-85-004F |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
DISPERSAL |
ERAD |
EPA 600/8-85-004F |
|
Region 9 Library/San Francisco,CA |
02/26/2013 |
ESAD |
EPA 600-8-85-004A |
|
Region 10 Library/Seattle,WA |
03/23/2010 |
ESAD |
EPA 600-8-85-004 F |
|
Region 10 Library/Seattle,WA |
01/02/1998 |
NTIS |
PB85-181097 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
NTIS |
PB86-125507 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
1 volume (various pagings) : illustrations ; 28 cm |
Abstract |
1,3-Butadiene has been shown to be an indirect mutage in bacteria. Two of its potential metabolites, 3,4- epoxybutene and diepoxybutane, are genotoxic in prokaryote as well as eukaryote test systems. Exposure of rodents to 1,3-butadiene results in ovarian tumors in mice and testicular tumors in rats, which offers suggestive evidence that 1,3-butadiene (or a motabolite of 1,3-butadiene) may reach the germ cells. There is also evidence that the dimer of 1,3-butadiene, 4-vinyl-1-cyclohexene, causes ovarian tumors in mice. The total body of evidence, including metabolism, mutagenicity and carcinogenicity data, suggests that 1,3-butadiene may present a genetic risk to humans. However, mutagenicity studies in mammalian test systems should be conducted to further characterize the mutagenic potential of 1,3-butadiene. On the basis of sufficient evidence from studies in two species of rodents, and inadequate epidemiologic data, 1,3-butadiene can be classified, according to EPA's Proposed Guidelines for Carcinogen Risk Assessment, as a 'probable' human carcinogen, Group B2. Using the classification scheme of the International Agency for Research on Cancer, 1,3-butadiene would be classified as a 'probable' human carcinogen, Group 2B. |
Notes |
"Final report." Distributed to depository libraries in microfiche. "September 1985." Includes bibliographical references (pages 7-1-7-7). "EPA-600/8-85-004F." |
Place Published |
Washington, D.C. |
Supplementary Notes |
See also PB85-181097. |
Corporate Au Added Ent |
United States. Environmental Protection Agency. Office of Health and Environmental Assessment. |
PUB Date Free Form |
1985 |
NTIS Prices |
PC A07/MF A01 |
BIB Level |
m |
Document Type |
BC |
Medium |
unmediated |
Content |
text |
Carrier |
volume |
Cataloging Source |
OCLC/T |
Merged OCLC records |
14585826 |
OCLC Time Stamp |
20160419144114 |
Language |
eng |
SUDOCS Number |
EP 1.23/9:600/8-85/004 F |
Origin |
OCLC |
Type |
MERGE |
OCLC Rec Leader |
01666cam 2200433Ia 45020 |