Main Title |
Assessment of Reproductive Risks (Journal Version). |
Author |
Clegg, E. D. ;
Sakai, C. S. ;
Voytek, P. E. ;
|
CORP Author |
Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. |
Publisher |
1985 |
Year Published |
1985 |
Report Number |
EPA/600/J-85/501; |
Stock Number |
PB89-134746 |
Additional Subjects |
Pesticides ;
Toxicology ;
Reproduction(Biology) ;
Hazardous materials ;
Teratogens ;
Laboratory animals ;
Humans ;
Males ;
Females ;
Regulations ;
Tests ;
Concentration(Composition) ;
Exposure ;
Methodology ;
Reprints ;
Risk assessment
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-134746 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
14p |
Abstract |
In the regulatory process, the hazards posed by potentially toxic agents to the female and male reproductive systems and to developing young are evaluated by risk assessment procedures. In the paper, toxicity testing and the regulatory process are discussed, with emphasis on risk assessment. The suggested testing protocols of the Pesticide Assessment Guidelines (U.S. EPA) are presented as an example of testing that might be done to produce toxicity data for an agent. Protocols and end points that are utilized in testing for reproductive effects are described. Included are acute, subchronic, chronic, and short-term tests. The four components of reproductive risk assessment (hazard identification, dose-response assessment, exposure assessment, and risk characterization) are examined. Effects of dibromochloropropane on rabbit testicular parameters are used to demonstrate approaches that could be taken in doing a reproductive risk assessment. Research needs are identified. Areas in which changes in reproductive risk assessment are anticipated, as well as the mechanism for influencing the nature and extent of those changes are discussed. |
Supplementary Notes |
Pub. in Biology of Reproduction, v34 p5-16 1986. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Assessment of Reproductive Risks (Journal Version). |
Category Codes |
57Y; 57P; 57U; 68G; 44G |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/21 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
905521108 |
Origin |
NTIS |
Type |
CAT |