| Main Title |
Chromosome Aberration Assay in the Chinese Hamster Ovary (CHO) Cells with Test Article Sodium Dimethyldithiocarbamate with Cover Letter dated 01/17/86. |
| CORP Author |
Microbiological Associates, Bethesda, MD.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
Jan 1986 |
| Year Published |
1986 |
| Report Number |
FYI-OTS-0186-0476; |
| Stock Number |
OTS-0000476-0 |
| Additional Subjects |
Pesticides ;
Environmental health ;
Public health ;
Assays ;
Chromosome aberration assay ;
Chinese hampster ovary cells ;
Sodium dimethyldithiocarbamatewith
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000476-0 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
101p |
| Abstract |
The text article, Sodium dimethyldithiocarbamate, was tested in the chromosome aberration assay using Chinese hamster ovary cells. The assay was conducted both in the absence and presence of an Aroclor-induced S-9 activation system at dose levels of 3, 1, 0.3, 0.1 nl/ml and 20, 10, 3, 1 nl/ml. respectively. A delayed harvest was also carried out at 3 and 1 nl/ml in the absence of S-9 and at 20 nl/ml in the presence of S-9 because of cell cycle delay at this dose level. A statistically significant increase in structural chromosome aberrations was observed at the highest dose tested in the presence of S-9. No increase was observed in the nonactivated study. Sodium dimethylidithiocarbamate was conducted to be suspect in the CHO chromosome aberration assay in the presence of S-9 and negative in the absence of S-9. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
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| Category Codes |
57U; 68 |
| NTIS Prices |
PC A07/MF$25.00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019100060 |
| Origin |
NTIS |
| Type |
CAT |
