| Main Title |
Toluene Blood Level following Subcutaneous Injection of Toluene in the Rat. |
| Author |
Benignus, V. A. ;
Muller, K. E. ;
Barton, C. N. ;
Bittikofer, J. A. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. Dept. of Psychology. ;Duke Univ. Medical Center, Durham, NC. Clinical Chemistry Lab. |
| Year Published |
1984 |
| Report Number |
EPA/600/J-84/144; |
| Stock Number |
PB85-124527 |
| Additional Subjects |
Toluene ;
Bioassay ;
Toxicology ;
Rats ;
Laboratory animals ;
Blood chemical analysis ;
Dosage ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB85-124527 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
15p |
| Abstract |
A model of toluene level in blood following subcutaneous injection of toluene mixed with polyoxyethylated-vegetable-oil vehicle was developed. The purpose was to provide a means of predicting dose received for subsequent toxicologic studies for any time and dose combination. The pharmacokinetics were of secondary interest. Using data from 111 rats, a four-parameter equation was devised to predict the time course of toluene blood level from 20-480 min post dosing, for dose levels of 50-1000 mg/kg. Blood concentrations rose at a rate which was independent of dose level. Maximum blood levels were uniquely determined by dose level. Blood levels fell at different rates depending upon dose level. Injection exposure, when compared to inhalation, has the advantages of (a) low expense, (b) low equipment requirements, and (c) simplicity. The disadvantage is, for some experiments, poor temporal simulation of the normal route of administration, inhalation. |
| Supplementary Notes |
Prepared in cooperation with North Carolina Univ. at Chapel Hill. Dept. of Psychology and Duke Univ. Medical Center, Durham, NC. Clinical Chemistry Lab. |
| Availability Notes |
Pub. in Environmental Research 33, p441-453 1984. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Toluene Blood Level following Subcutaneous Injection of Toluene in the Rat. |
| PUB Date Free Form |
c1984 |
| Category Codes |
6T; 6O; 57Y; 57Q |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
504625694 |
| Origin |
NTIS |
| Type |
CAT |
