Main Title |
Toluene Levels in Blood and Brain of Rats as a Function of Toluene Level in Inspired Air. |
Author |
Benignus, V. A. ;
Muller, K. E. ;
Graham, J. A. ;
Barton, C. N. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ., Chapel Hill. |
Year Published |
1984 |
Report Number |
EPA/600/J-82-010; |
Stock Number |
PB84-197532 |
Additional Subjects |
Toluene ;
Toxicology ;
Blood ;
Brain ;
Rats ;
Laboratory animals ;
Reprints ;
Air pollution effects(Animals)
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB84-197532 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
The relationship of toluene concentration in blood and brain to the concentration of toluene in inspired air has not been explicitly studied. Sixty rats were exposed by inhalation to 50, 100, 500, or 1000 ppm toluene for 3 hr. Immediately following exposure, venous blood samples and whole brains were collected and assayed for toluene levels. For several empirical reasons, the natural logarithm (log) of toluene tissue levels were predicted in a linear model from log toluene levels in air. An additional 10 rats were exposed to 550 ppm toluene for 8 hr in order to verify that the 3-hr exposure was sufficient to produce near-asymptotic levels of toluene in blood and brain. Log brain toluene concentration was significantly higher than log blood concentration by an additive constant. The ration of brain to blood toluene level was estimated as 1.56/1. Three- and eight-hour exposure results did not differ, thus indicating that these results would hold for toluene exposures of 3 hr or greater. |
Supplementary Notes |
Pub. in Environmental Research 33, p39-46 1984. Prepared in cooperation with North Carolina Univ., Chapel Hill. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Toluene Levels in Blood and Brain of Rats as a Function of Toluene Level in Inspired Air. |
PUB Date Free Form |
1984 |
Category Codes |
6T; 57Y |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
423020787 |
Origin |
NTIS |
Type |
CAT |