Main Title |
Effects of Low Subchronic Doses of Methoxychlor on the Rat Hypothalamic-Pituitary Reproductive Axis. |
Author |
Goldman, J. M. ;
Cooper, R. L. ;
Rehnberg, G. L. ;
Hein, J. F. ;
McElroy, W. K. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1986 |
Report Number |
EPA/600/J-86/316; |
Stock Number |
PB87-176889 |
Additional Subjects |
Reproduction(Biology) ;
Pesticides ;
Hypothalamus ;
Gonadotropic hormones ;
Reproductive system ;
Male genital diseases ;
Fertility ;
Rats ;
Reprints ;
Methoxychlor ;
Infertility
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB87-176889 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
11p |
Abstract |
The purpose of this study was to explore the influence of methoxychlor (MXC) upon the pituitary and hypothalamic components of the male reproductive system at dose levels that were without detectable testicular effects. At 21 days, male Long-Evans rats were gavaged daily with 25 or 50 mg/kg MXC in corn oil. Controls received vehicle only. After 8 weeks of dosing, no significant changes were seen in serum LH, FSH, or prolactin, nor in the pituitary concentrations of LH or FSH. Pituitary prolactin was elevated for both doses, and pituitary fragments perifused in vitro released more prolactin than controls. The concentration of gonadotropin-releasing hormone (GnRH) was higher in the mediobasal hypothalamus, but only for the 50 mg/kg group. At this dose, there was a corresponding increase in the KCL-stimulated release of GnRH. The data suggest that previously reported reproductive effects of MXC may be mediated, at least in part, through an elevation in prolactin concentration and release, which in turn is able to influence hypothalamic levels in GnRH. |
Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology 86, p474-483 1986. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Effects of Low Subchronic Doses of Methoxychlor on the Rat Hypothalamic-Pituitary Reproductive Axis. |
PUB Date Free Form |
1986 |
Category Codes |
68E; 68G; 57S; 57H; 57Y |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
716921374 |
Origin |
NTIS |
Type |
CAT |