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Main Title Aerosol Therapy Implications of Particle Deposition Patterns in Simulated Human Airways.
Author Martonen, T. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;North Carolina Univ. at Chapel Hill. Dept. of Medicine.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/056;
Stock Number PB91-191635
Additional Subjects Aerosols ; Drug administration routes ; Trachea ; Bronchi ; Inhalation ; Humans ; Bronchial neoplasms ; Respiratory system ; Anatomical models ; Reprints ; Particle deposition
Library Call Number Additional Info Location Last
NTIS  PB91-191635 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 18p
Abstract The efficacy of inhalation therapy may be improved by the selective deposition of aerosolized medicines, by explicitly targeting and delivering drugs to prescribed lung sites. Here, the deposition patterns of test aerosols, mapped in surrogate respiratory tracts consisting of replica laryngeal casts and fabricated tracheobronchial models, are analyzed. Particles were preferentially deposited at bifurcations, specifically at carinal ridges. Evidence from other investigations indicates that mucociliary clearance may be impeded at such sites in vivo. When these two effects are coupled, the findings suggest that epithelial cells and receptors at airway branching sites may receive concentrated doses of inhaled pharmacological agents. To focus the effects of airborne drugs the lung should, therefore, be considered as a serial network of Y-shaped bifurcation units. The findings have important implications to aerosol therapy protocols including: (1) the treatment of bronchogenic carcinomas because malignant tumors have a predilection for upper airway bifurcations; and (2) lung diseases related to the afferent nervous system since components of neural pathways frequent such locations.
Supplementary Notes Pub. in Jnl. of Aerosol Medicine, v4 n1 p25-40 Feb 91. Prepared in cooperation with North Carolina Univ. at Chapel Hill. Dept. of Medicine.
NTIS Title Notes Journal article.
Title Annotations Reprint: Aerosol Therapy Implications of Particle Deposition Patterns in Simulated Human Airways.
Category Codes 57Q; 57S
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 119326372
Origin NTIS
Type CAT