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Main Title Surrogate Experimental Models for Studying Particle Deposition in the Human Respiratory Tract.
Author Martonen, T. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/D-85/158;
Stock Number PB85-237857
Additional Subjects Respiratory system ; Models ; Humans ; Exposure ; Aerosols ; Lung ; Particulates ; Air pollution effects(Humans)
Library Call Number Additional Info Location Last
NTIS  PB85-237857 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 60p
Abstract Hazard assessment following challenge by ambient aerosols requires accurate estimation of exposure, that is, determination of the total mass of particulate matter deposited within the respiratory tract, and its intercompartmental distribution. Aerosol deposition studies utilizing human test subjects yield valuable information on the deposition of inhaled particles in man, but experimental regimens lack the resolution to quantitate 'hot spots' within the lung. Aerosol deposition experiments with respiratory tract surrogates, or models, can be designed to be complimentary to human studies. The authors have put experimental modelling efforts into perspective per their applicability for the risk assessment of inhaled ambient aerosols. Heterogeneity of deposition has been detected in in vitro experiments over a wide range of particulate sizes and flow rate magnitudes--in a variety of surrogate larynx-TB models, for both constant and time-dependent flow patterns, and for both phases (inspiration and expiration) of a breathing cycle.
PUB Date Free Form Aug 85
Category Codes 6F; 6P; 68A; 57S
NTIS Prices PC A04/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 529824306
Origin NTIS
Type CAT