Main Title |
Development of a Protocol to Assess Reproductive Effects of Toxicants in the Rat. |
Author |
Gray, L. E. ;
Ostby, J. ;
Sigmon, R. ;
Ferrell, J. ;
Rehnberg, G. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1988 |
Year Published |
1988 |
Report Number |
EPA/600/J-88/342; |
Stock Number |
PB89-237424 |
Additional Subjects |
Herbicides ;
Animal physiology ;
Toxicity ;
DDT ;
Dosage ;
Rats ;
Sex behavior ;
Lindane ;
Male ;
Female ;
Reproduction(Biology) ;
Reprints ;
Carbendazim ;
Dibutyl phthalate
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-237424 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
The determination that a chemical poses a reproductive risk to man typically relies upon fertility studies using rodents. However, fertility in rodents is often difficult to disrupt and more sensitive indicators of reproductive function should be included in the risk assessment process. The present discussion compares the sensitivity of fertility to other endpoints following exposure to known reproductive toxicants. In the studies rats were dosed from weaning through puberty, gestation, and lactation. The reproductive function of the male, the female, and the offspring was assessed. The effects of methoxychlor, carbendazim (MBC), dibutyl phthalate (DBP), and lindane are discussed and compared to fertility. The data from the studies indicate that no single endpoint will consistently be the most sensitive indicator of reproductive toxicity. Studies must include a number of well validated endpoints that provide a comprehensive assessment of the entire reproductive system of the male and female. |
Supplementary Notes |
Pub. in Reproductive Toxicology, v2 p281-287 1988. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Development of a Protocol to Assess Reproductive Effects of Toxicants in the Rat. |
Category Codes |
57Y; 68E |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
931318619 |
Origin |
NTIS |
Type |
CAT |