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Main Title Eyeblink Conditioning in the Developing Rat.
Author Stanton, M. E. ; Skelton, R. W. ; Freeman, J. H. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Victoria Univ. (British Columbia). ;North Carolina Univ. at Chapel Hill.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/336;
Stock Number PB92-232982
Additional Subjects Conditioning(Learning) ; Rats ; Acoustic stimulation ; Development ; Nervous system ; Reprints ; Eyeblink
Library Call Number Additional Info Location Last
NTIS  PB92-232982 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Abstract Long-Evans rat pups, 17-18 or 24 days of age, were trained with an eyeblink conditioning (EBC) procedure that has recently been used with adult rats. Pups received 3 sessions of delay conditioning in a single day, at about 4 hour intervals (100 trials/session). Trials involved pairings of an auditory conditioned stimulus (2.8 KHZ, 82 dB tone), and a periocular-shock unconditioned stimulus (US, 100msec, 2 mA), presented 280-msec apart. EBC was observed at both ages, but older pups learned much more rapidly. Subsequent experiments established that the effect is associative (Experiment 2), that age differences in EBC cannot be attributed to differences in the ability to respond or in sensitivity to the US (Experiment 3); and that EBC can be modulated by motivational state (Experiment 4). These results indicate that EBC can be studied in the developing rat. Further use of the preparation could help elucidate the relation between neural development and the ontogeny of learning.
Supplementary Notes Pub. in Behavioral Neuroscience, v106 n4 p657-665 Aug 92. Prepared in cooperation with Victoria Univ. (British Columbia), and North Carolina Univ. at Chapel Hill.
NTIS Title Notes Journal article.
Title Annotations Reprint: Eyeblink Conditioning in the Developing Rat.
Category Codes 57S
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 231129187
Origin NTIS
Type CAT