| Main Title |
Development of an in vitro model for screening organophosphates for neurotoxicity (pilot study) / |
| Author |
Graham, Doyle G.
|
| Other Authors |
|
| CORP Author |
Duke Univ. Medical Center, Durham, NC. Dept. of Pathology.;Health Effects Research Lab., Cincinnati, OH. |
| Publisher |
Health Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, |
| Year Published |
1980 |
| Report Number |
EPA-600/1-80-016.; EPA-68-02-2953 |
| Stock Number |
PB80-169428 |
| OCLC Number |
20699093 |
| Subjects |
Organophosphorus compounds--Toxicology ;
Organophosphorus Compounds--toxicity ;
Nerve Degeneration
|
| Additional Subjects |
Toxicology ;
Phosphorus organic compounds ;
In vitro analysis ;
Models ;
Development ;
Toxicity ;
Neuroblastoma ;
Cell lines ;
Tissue cultures ;
Neurotoxins ;
Norepinephrine ;
Parathion ;
Phosphorothioic acid/o-o-(dimethyl-ester)-o-(nitrophenyl-ester) ;
Folex ;
DEF-6 pesticide ;
EPN insecticide ;
Phasvel ;
TOCOP pesticide
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD |
EPA 600-1-80-016 |
|
Headquarters Library/Washington,DC |
04/24/2014 |
| EKBD |
EPA-600/1-80-016. |
|
Research Triangle Park Library/RTP, NC |
10/05/2001 |
| ELBD ARCHIVE |
EPA 600-1-80-016 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| ELBD |
EPA 600-1-80-016 |
|
AWBERC Library/Cincinnati,OH |
06/04/1999 |
| NTIS |
PB80-169428 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
iv, 36 p. : ill. ; 28 cm. |
| Abstract |
An in vitro model utilizing neuroblastoma cell lines was developed for the differentiation of organophosphorus compounds which have the potential for induction of delayed degeneration of peripheral nerves and the spinal cord. IMR-32 neuroblastoma cells, derived from a human tumor, showed specific (3H)-norepinephrine uptake. The greater effect of alkyl over aryl OP compounds suggests a relationship with water solubility, thus equilibrium between adsorption to agar and the surrounding medium or lysosomal contents. The effect of parathion was intermediate, less than that for merphos, DEF and EPN but greater than that for leptophos and TOCP. Electron microscopic observations suggest further studies to define a morphologic lesion peculiar to the clinically delayed neurotoxic OP compounds. |
| Notes |
Includes bibliographical references (p. 33-35). "EPA-600/1-80-016". "February 1980". "Final Report". Interagency Contract No. 68-02-2953. |
| Place Published |
Research Triangle Park, N.C. |
| Access Notes |
Also available via the World Wide Web. |
| Corporate Au Added Ent |
Health Effects Research Laboratory (Research Triangle Park, N.C.) |
| PUB Date Free Form |
1980 |
| NTIS Prices |
PC A03/MF A01 |
| BIB Level |
m |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20120125131621 |
| Language |
eng |
| Origin |
OCLC |
| Type |
MERGE |
| OCLC Rec Leader |
01145cam 2200301Ia 45020 |
