Main Title |
Age-Related Alterations in the Stimulated Release In vitro of Catecholamines and Luteinizing Hormone-Releasing Hormone from the Male Rat Hypothalamus. |
Author |
Goldman, J. M. ;
Cooper, R. L. ;
Rehnberg, G. L. ;
Gabel, S. ;
McElroy, W. K. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.;Iowa Univ., Iowa City. Coll. of Medicine. |
Year Published |
1987 |
Report Number |
EPA/600/J-87/128; |
Stock Number |
PB88-144423 |
Additional Subjects |
Catecholamines ;
Aging(Biology) ;
Hypothalamus ;
Norepinephrine ;
Dopamine ;
Rats ;
Tissues(Biology) ;
Reprints ;
LH-FSH releasing hormone ;
Tissue culture ;
Electric stimulation
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB88-144423 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
Using an in vitro perifusion system, the present study investigated the possibility that alterations in catecholamine and luteinizing hormone-releasing hormone (LHRH) secretion from the male rat mediobasal hypothalamus are present during the period of middle-age. The results indicate that, while tissue concentrations and baseline secretion of norepinephrine, dopamine and LHRH were similar between age groups, the patterns of dopamine and LHRH release in response to a series of depolarizing stimuli was different in the older animals. After all challenges, dopamine concentrations in the perifusate declined much more sharply for the middle-aged group, a finding that may be associated with a decrease with age in the pool of transmitter available for ready release. (Copyright (c) 1987 Plenum Publishing Corporation.) |
Supplementary Notes |
Pub. in Neurochemical Research, v12 n7 p651-657 1987. Prepared in cooperation with National Inst. of Environmental Health Sciences, Research Triangle Park, NC. Sponsored by Iowa Univ., Iowa City. Coll. of Medicine. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Age-Related Alterations in the Stimulated Release In vitro of Catecholamines and Luteinizing Hormone-Releasing Hormone from the Male Rat Hypothalamus. |
PUB Date Free Form |
c1987 |
Category Codes |
57; 57S; 57I; 57B |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
808419207 |
Origin |
NTIS |
Type |
CAT |