Main Title |
Triggering of a Cytolytic Factor with TNF-Like Activity from Human Monocytes. |
Author |
Koren, H. S. ;
McKinnon, K. P. ;
Chen, A. R. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Clinical Research Branch. ;Duke Univ. Medical Center, Durham, NC. |
Year Published |
1986 |
Report Number |
EPA/600/D-86/127; |
Stock Number |
PB87-129565 |
Additional Subjects |
Monocytes ;
Humans ;
Protein ;
Toxicity ;
In vivo analysis ;
Cytolytic factor ;
TNF ;
Cytolytic monokine
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB87-129565 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
36p |
Abstract |
Monocytes have a nonoxidative mechanism of tumor cytolysis operative in CGD and in normal monocytes under anaerobic conditions. The absence of competitive inhibition provides negative evidence for a contact-independent mechanism of cytolysis, confirmed by the demonstration of a soluble mediator secreted independently of effector-target cell contact. This cytolytic monokine, a protein of apparent molecular weight between 25,000 and 40,000, resembles TNF functionally and antigenically. Further work will be required to demonstrate its biochemical identity, its precise mechanism of toxicity, and the extent of its importance in vivo. |
Supplementary Notes |
Prepared in cooperation with Duke Univ. Medical Center, Durham, NC. |
PUB Date Free Form |
Jul 86 |
Category Codes |
57F; 57B |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
706516722 |
Origin |
NTIS |
Type |
CAT |