| Main Title |
Comparability of In vitro and In vivo Methods for the Determination of Alterations in Drug Metabolism. |
| Author |
Carlson, G. P. ;
Chadwick, R. W. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Purdue Univ., Lafayette, IN. School of Pharmacy and Pharmacal Sciences. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/316; |
| Stock Number |
PB88-196332 |
| Additional Subjects |
Liver ;
Metabolism ;
Drugs ;
Toxicity ;
Laboratory animals ;
Humans ;
In vitro analysis ;
In vivo analysis ;
Comparison ;
Substrates ;
Antipyrine ;
Models ;
Evaluation ;
Reprints ;
Xenobiotics
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-196332 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
16p |
| Abstract |
The article reviews the use of model substrates to assess the capacity of the liver to metabolize xenobiotics via the myriad of drug metabolizing pathways available to it. The applicability of model compounds to act as predictors of in vivo drug metabolism in man and animals was evaluated, and the advantages and limitations of these assays are indicated. (Copyright (c) 1987 Elsevier Science Publishers B.V. (Biomedical Division.) |
| Supplementary Notes |
Pub. in Toxicology Letters, v39 p125-138 1987. Prepared in cooperation with Purdue Univ., Lafayette, IN. School of Pharmacy and Pharmacal Sciences. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Comparability of In vitro and In vivo Methods for the Determination of Alterations in Drug Metabolism. |
| PUB Date Free Form |
c1987 |
| Category Codes |
57Q; 57Y |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
817624682 |
| Origin |
NTIS |
| Type |
CAT |
