| Main Title |
Dimethyltin Dichloride: Investigations into Its Gastrointestinal Absorption and Transplacental Transfer. |
| Author |
Noland, E. A. ;
McCauley, P. T. ;
Bull, R. J. ;
|
| CORP Author |
Health Effects Research Lab., Cincinnati, OH. |
| Year Published |
1983 |
| Report Number |
EPA-600/J-83-220; |
| Stock Number |
PB84-213149 |
| Additional Subjects |
Toxicology ;
Rats ;
Laboratory animals ;
Absorption ;
Gastrointestinal system ;
Reprints ;
Dimethyltin dichloride ;
DMDC ;
Water pollution effects(Animals)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB84-213149 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
12p |
| Abstract |
Dimethyltin dichloride (DMDC) is commonly used as a stabilizer in PVC pipe used for transport of potable water. Learning deficiencies have been observed postnatally in pups from DMDC-treated dams. Studies were conducted with female Sprague-Dawley rats to determine whether DMDC was absorbed by the dam and transferred across the placenta to fetal blood and brain tissue. This was accomplished in three phases: (1) a comparison of absorption of organic and inorganic tin from drinking water, (2) a comparison of prenatal and postnatal levels of tin in the pups in cross-fostering studies, and (3) a (14C)dimethyltin dichloride tracer study to determine whether organic tin passed to the pup intact. Major findings include: (1) DMDC is absorbed in the gastrointestinal tract of the dam much more rapidly than Sn2+; (2) the more rapid absorption of DMDC results in higher concentration of tin in fetal blood and brain; and (3) in fetuses that receive tin as DMDC, both tin and the methyl carbon are absorbed by the dam and transferred to the blood and brain of the fetuses. |
| Supplementary Notes |
Pub. in Toxicology and Environmental Health 12, p89-98 1983. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Dimethyltin Dichloride: Investigations into Its Gastrointestinal Absorption and Transplacental Transfer. |
| PUB Date Free Form |
1983 |
| Category Codes |
6T; 6F; 57Y; 68F |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
427225120 |
| Origin |
NTIS |
| Type |
CAT |
