Main Title |
Comparability of Rat and Human Visual-Evoked Potentials. |
Author |
Hudnell, H. K. ;
Boyes, W. K. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. |
Publisher |
c1991 |
Year Published |
1991 |
Report Number |
EPA/600/J-91/057; |
Stock Number |
PB91-191643 |
Additional Subjects |
Visual evoked potentials ;
Comparative evaluations ;
Rats ;
Humans ;
Diazepam ;
Amplitude ;
Species specificity ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB91-191643 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
8p |
Abstract |
A series of experiments was conducted to assess the comparability of physiological processes in rat and human visual systems. In the first set of experiments, transient visual evoked potentials (VEPs) were elicited by the onset of sine-wave gratings of various spatial frequencies. The spatial frequency-response profiles of the first positive and immediately succeeding negative components differed from one another, but were similar in the two species. In addition, amplitude of the negative, but not the positive, component was strongly attenuated in both species following stationary pattern adaptation. In the second set of experiments, steady-state VEPs were elicited by the onset and offset of the gratings. The spatial frequency profiles of the 1F (response amplitude at the frequency of stimulus onset-offset) and 2F response components differed from one another, but were similar in both species. The final set of experiments indicated that diazepam, a GABA agonist, reduced amplitude of 2F, but not 1F, in both species. |
Supplementary Notes |
Pub. in Neuroscience and Biobehavioral Reviews, v15 p159-164 Mar 91. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Comparability of Rat and Human Visual-Evoked Potentials. |
Category Codes |
57I |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
119326381 |
Origin |
NTIS |
Type |
CAT |