||Rat and Human Visual-Evoked Potentials Recorded Under Comparable Conditions: A Preliminary Analysis to Address the Issue of Predicting Human Neurotoxic Effects from Rat Data.
Hudnell, H. K. ;
Boyes, W. K. ;
Otto., D. A. ;
||Environmental Protection Agency, Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill.
Nervous system ;
Spatial distribution ;
Visual evoked potentials ;
Species specificity ;
Predictive value of tests
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||A search was undertaken for contributions of sustained and transient visual elements to the rat visual-evoked potential (VEP) using procedures similar to those used in humans. Evoked potentials were recorded following either pattern-reversal or pattern-onset stimulation over a range of spatial frequencies, and following adaptation to a stationary grating of the same spatial frequency as the test stimulus. The initial VEP component, a positive peak labeled P1, was early in latency, larger at lower spatial frequencies, larger following pattern-reversal than pattern-onset stimulation, and not reduced in amplitude by adaptation to a stationary grating. These properties suggest that P1 reflects the activity of a transient, motion-perception visual subsystem. Subsequent in latency to P1 was a negative peak labeled N2 which was largest at intermediate spatial frequencies, larger following pattern-onset than pattern-reversal stimulation, and reduced in amplitude by adaptation to a stationary grating. These properties suggest that N2 reflects the activity of a pattern-perception visual subsystem.
||Pub. in Neurotoxicology and Teratology, v12 n4 p391-398 Aug 90. Prepared in cooperation with North Carolina Univ. at Chapel Hill.
|NTIS Title Notes
||Reprint: Rat and Human Visual-Evoked Potentials Recorded Under Comparable Conditions: A Preliminary Analysis to Address the Issue of Predicting Human Neurotoxic Effects from Rat Data.
||PC A02/MF A01