Main Title |
Health assessment document for nickel and nickel compounds : final report. |
Author |
Bayard, S. ;
Beliles, R. ;
Brooks, G. ;
Chu, M. ;
Crocetti, A.
|
CORP Author |
United States. Environmental Protection Agency. |
Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, |
Year Published |
1986 |
Report Number |
EPA/600/8-83/012 FF |
Stock Number |
PB86-232212 |
OCLC Number |
15027127 |
Subjects |
Nickel--Toxicology ;
Nickel compounds--Toxicology
|
Additional Subjects |
Nickel--Toxicology ;
Public health ;
Environmental surveys ;
Distribution ;
Toxicology ;
Assessments ;
Risk ;
Physical properties ;
Chemical properties ;
Metals ;
Health risks ;
Heavy metals ;
Cancer
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EHAM |
RA1231.N44H42 1986 |
|
Region 1 Library/Boston,MA |
04/29/2016 |
EJED |
EPA 600/8-83-012FF |
|
OCSPP Chemical Library/Washington,DC |
01/01/1988 |
EKBD |
EPA/600/8-83/012FF |
|
Research Triangle Park Library/RTP, NC |
08/02/1996 |
ELBD ARCHIVE |
EPA 600-8-83-012FF |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
ELBD |
EPA 600-8-83-012FF |
|
AWBERC Library/Cincinnati,OH |
01/28/1989 |
ERAD |
EPA 600/8-83/012 FF |
|
Region 9 Library/San Francisco,CA |
02/26/2013 |
ESAD |
EPA 600-8-83-012FF |
|
Region 10 Library/Seattle,WA |
07/29/2005 |
NTIS |
PB86-232212 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
1 volume (various pagings) : illustrations ; 28 cm |
Abstract |
The predominant atmospheric forms of nickel are as sulfate, oxides, and complex oxides. Nickel also occurs in ambient and drinking waters and soils. Routes of intake for man are inhalation, ingestion, and percutaneous absorption. Pulmonary absorption varies according to chemical and physical form of the compound. While gastrointestinal intake ranges from 300 to 500 microgram daily, absorption is only one to ten percent of intake. Percutaneous absorption, usually through contact with nickel alloys in the household, is related to hypersensitivity and skin disorders. Inhaled nickel compounds lead to highest levels in lung, brain, kidney, and liver. Nickel exposure produces chronic dermatological, respiratory, endocrine and cardiovascular effects. Reproductive and developmental effects have been found in animals but not humans. Various nickel compounds have been tested for mutagenicity, demonstrating the ability of nickel compounds to produce genotoxic effects; the translation of these effects into actual mutations is still not clearly understood. There is evidence both in humans and animals for the carcinogenicity of nickel in some forms. Lifetime cancer risks for continuous inhalation exposure at 1 microgram nickel/cu. m. have been estimated for nickel refinery dust and nickel subsulfide. There is growing evidence that nickel may be an essential element for humans. |
Notes |
Distributed to depository libraries in microfiche. "September 1986." Includes bibliographical references. "EPA/600/8-83/012FF." |