Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Acute Vapor Inhalation Study in Fischer 344 Rats Using Aerothene Tt with Cover Letter Dated 03/22/1988.
CORP Author Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1988
Report Number 86-880000173
Stock Number OTS0514062
Additional Subjects Toxicology ; Health effects ; 1 ; 1 ; 1-trichloroethane (71-55-6) ; Acute Toxicity ; Mammals ; Rats ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 71-55-6
Library Call Number Additional Info Location Last
NTIS  OTS0514062 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 34p
Acute inhalation toxicity was evaluated in groups of 5 male and 5 female Fischer 344 rats exposed to Aerothene TT (1,1,1-trichloroethane) at actual concentrations of 15,523, 18,425, or 21,063 ppm for 4 hours. Mortality was observed in 3 females in the 18,425 ppm dose group and all animals in the highest dose group. The LC50 value was reported to be between 18,425 - 21,063 ppm for males and calculated to be 18,000 ppm (16,600-19,400 ppm 95% confidence limits) for females by the moving average method. Clinical observations included lethargy and unresponsiveness. Gross necropsy revealed clear facial soiling and visceral congestion.