Abstract |
The beryllium ion, energetic inhibitor of alkaline phosphatase when the metallic component of the phosphatase has not been disassociated, reactivates the enzyme after prolonged dialysis. It follows from this that, id the Be(++) ion is an energetic inhibitor of alkaline phosphatase in the tissues and their extracts, the modalities of its action on the purified enzyme are identical to those of other cations, particularly Zn(++). The interchangeability of divalent metals in the reactivation of alkaline phosphatase and their competition in the reconstitution of the enzyme molecule disassociated through dialysis appear therefore to be general. |