Main Title |
Initiation, Promotion, and Complete Carcinogenesis by N-Methyl-N'-Nitro-N-Nitrosoguanidine or Ethylnitrosourea in the SENCAR Mouse Skin Tumorigenesis Model. |
Author |
O'Connell, J. F. ;
Nesnow, S. ;
Slaga, T. J. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC.;Texas Univ. System Cancer Center, Smithville. |
Year Published |
1987 |
Report Number |
EPA/600/J-87/318; |
Stock Number |
PB88-196043 |
Additional Subjects |
Nitro compounds ;
Carcinogens ;
Skin cancer ;
Mice ;
Neoplasms ;
Pharmacology ;
Toxicity ;
Reprints ;
Ethylnitrosourea ;
Methylnitronitrosoguanidine ;
Skin neoplasms ;
Papilloma ;
Cocarcinogenesis
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB88-196043 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
12p |
Abstract |
Five doses of either N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or ethylnitrosourea (ENU) were tested as complete carcinogens, tumor initiators and tumor promoters in the SENCAR skin tumorigenesis model. As tumor initiators, MNNG-induced papillomas at all doses tested, while ENU was active from 10-40 micromol. As complete carcinogens, MNNG from doses of 0.5-5.0 micromol and ENU from doses of 10 micromol-40 micromol were potent inducers of both papillomas and carcinomas indicating that these agents are active as both tumor initiators and tumor promoters. (Copyright (c) 1987 Elsevier Scientific Publishers Ireland Ltd.) |