Main Title |
Twenty-eight Day Subchronic Dermal Toxicity Study in Rats on API-HNC-1 (High Nitrogen Crude Petroleum Oil); API-SFP-105 (No. 1 Hydrotreated Shale Oil to 0.19% Nitrogen Level); API-SFP-206 (No. 2 Hydrotreated Shale Oil to 0.06% Nitrogen Level); API-SFR-1 (Raw Shale Oil No. 1) and API-SFR-2 (Raw Shale Oil No. 2). Final Report from Springborn Institute for Bioresearch, Inc. |
CORP Author |
American Petroleum Inst., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Publisher |
5 Sep 1985 |
Year Published |
1985 |
Report Number |
FYI-AX-0285-0381; |
Stock Number |
OTS-0000381-1 |
Additional Subjects |
Toxicity ;
Rats ;
Skin(Anatomy) ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS-0000381-1 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
337p |
Abstract |
The potential toxocities due to dermal exposure to six shale-derived hydrocarbon mixtures were evaluated using rats. Animals were dosed five days per week for four weeks. The application site was occluded six hours after dosing. Dose levels for each test article were 0.25 g/kg and 2.5 g/kg. The control group was sham treated. Body weights, food consumption, overt toxicity, and dermal responses were recorded. Blood was obtained at the end of the study and used for hematology and clinical chemistry evaluations. A selection of approximately twenty different organs or tissues from the control and high-dose animals plus all lesions was evaluated microscopically. |