Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title In vitro Screening Batteries for Neurotoxicants (Journal Article).
Author Veronesi, B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/260;
Stock Number PB92-206408
Additional Subjects Toxicology ; Nervous system ; In vitro analysis ; Tissue culture ; Cell line ; Cultured tumor cells ; Scanning electron microscopy ; Cell survival ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB92-206408 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/01/1993
Collation 12p
The need to develop, validate and utilize in vitro models to test chemicals for neurotoxic potential is widely appreciated. The lecture discusses the major advantages of using cell and tissue culture, the various in vitro models amenable for neurotoxicity studies, and the distinction between mechanistic and screening models. Considerations for designing screening batteries to evaluate neurotoxicants are discussed. Topics such as choice of appropriate cell models and endpoints (i.e. cytotoxic and neurotoxic), and technical considerations in the design of the battery are also presented. (Copyright (c) 1992 by Intox Press, Inc.)